The 22nd Operations Group directs the wings KC-135R Stratotanker and KC-46 Pegasus refueling and airlift operations in support of worldwide Air Mobility Command, U.S. Transportation Command, Air Force, Department of Defense, and allied operations anywhere in the world. With its 344th, 349th and 350th Air Refueling Squadrons, the group supervises operations in support of strategic force projection and mobility, special operations, tactical air operations, and humanitarian assistance efforts.

Through the 22nd Operations Support Squadron, the group provides airfield management, air traffic control, intelligence, combat crew communications, base weather service, mission scheduling, planning and combat tactics.

To execute the wing's challenging and diverse refueling and airlift missions, from  CONUS refueling support to unit deployments in support of theater operations worldwide.